| http://purl.uniprot.org/citations/18425376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18425376 | http://www.w3.org/2000/01/rdf-schema#comment | "Metastasis-associated genomic alterations have been recognized to play a critical role in tumor metastasis. Primary and metastatic tumor cells in mice and tumors in a patient were studied by cDNA array analysis. Selected genes were determined by RT-PCR and immunohistochemistry. Pathways on changed genes were statistically analyzed. The function of Grb2 was determined by in vitro wound assay. Nodal metastatic cells had a stronger ability of growth and metastasis than primary tumor cells. A total of 376 genes showed a different expression between primary and metastatic cells. The expression of Grb2 and genes in the Grb2-mediated pathways was significantly elevated in the metastases. Elevated levels of Grb2 expression in metastases were related to the distant metastasis of colorectal carcinoma. Blocking the Grb2-SH2 domain signaling transduction inhibited cell motility. Metastasis-associated genes identified by cDNA and tissue microarrays provide potentially valuable information on the metastasis of colorectal tumors. Overexpression of Grb2 may contribute to tumor growth, invasiveness and metastasis."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Dong D."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Wang J.J."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Long Y.Q."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Yu G.Z."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/author | "Mu X.L."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/pages | "1191-1204"xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/title | "New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/18425376 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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