| http://purl.uniprot.org/citations/18425393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18425393 | http://www.w3.org/2000/01/rdf-schema#comment | "Polymorphisms in the cytochrome P450 1B1 (CYP1B1) and glutathione S-transferase (GST) drug metabolic enzymes, which are responsible for metabolic activation/detoxification of estrogen and environmental carcinogens, were analyzed for their association with breast cancer risk in 541 cases and 635 controls from a North Carolina population. Each polymorphism, altering the catalytic function of their respective enzymes, was analyzed in Caucasian and African-American women. As reported in previous studies, individual polymorphisms did not significantly impact breast cancer risk in either Caucasian or African-American women. However, African-American women exhibited a trend towards a protective effect when they had at least one CYP1B1 119S allele (OR=0.53; 95% CI=0.20-1.40) and increased risk for those women harboring at least one CYP1B1 432V allele (OR=5.52; 95% CI=0.50-61.37). Stratified analyses demonstrated significant interactions in younger (age < or =60) Caucasian women with the CYP1B1 119SS genotype (OR=3.09; 95% CI=1.22-7.84) and younger African-American women with the GSTT1 null genotype (OR=4.07; 95% CI=1.12-14.80). A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02-4.41). In Caucasian women, the combined GSTP1 105IV/VV and CYP1B1 119AA genotypes resulted in a near 2-fold increase in risk (OR=1.96; 95% CI=1.04-3.72) and the three way combination of GSTP1 105IV/VV, CYP1B1 119AS/SS and GSTT1 null genotypes resulted in an almost 4-fold increase in risk (OR=3.97; 95% CI=1.27-12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Hu J.J."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Miller M.S."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Perrier N.D."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Shaw C.S."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Rubin P."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Levine E.A."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Freimanis R.I."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Van Emburgh B.O."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Allen G.O."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Carey L.A."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Mosley L.J."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Sawyer L.R."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/author | "Sherrill G.B."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/pages | "1311-1321"xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/title | "Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer."xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18425393 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18425393 |
| http://purl.uniprot.org/citations/18425393 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18425393 |
| http://purl.uniprot.org/uniprot/#_D0EZN5-mappedCitation-18425393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18425393 |
| http://purl.uniprot.org/uniprot/#_D0EZN6-mappedCitation-18425393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18425393 |
| http://purl.uniprot.org/uniprot/#_D0EZN7-mappedCitation-18425393 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18425393 |