http://purl.uniprot.org/citations/18426861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18426861 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.Research design and methodsTwo European population samples were studied: 1) one case-control cohort of 514 type 1 diabetic subjects and 2,027 control subjects and 2) one family cohort of 483 complete type 1 diabetic case-parent trios (total 997 affected). A total of 13 tag single nucleotide polymorphisms (SNPs) from the 10 type 2 diabetes loci were analyzed for type 1 diabetes association.ResultsNo association of type 1 diabetes was found with any of the 10 type 2 diabetes loci, and no age-at-onset effect was detected. By combined analysis using the Wellcome Trust Case-Control Consortium type 1 diabetes data, SNP rs1412829 in the CDKN2A/B locus bordered on significance (P = 0.039) (odds ratio 0.929 [95% CI 0.867-0.995]), which did not reach the statistical significance threshold adjusted for 13 tests (alpha = 0.00385).ConclusionsThis study suggests that the type 2 diabetes loci do not play any obvious role in type 1 diabetes genetic susceptibility. The distinct molecular mechanisms of the two diseases highlighted the importance of differentiation diagnosis and different treatment principles."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.org/dc/terms/identifier | "doi:10.2337/db08-0270"xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Hakonarson H."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Bradfield J.P."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Polychronakos C."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Grant S.F."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Qu H.Q."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/author | "Frackelton E."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/pages | "1983-1986"xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/title | "Association analysis of type 2 diabetes Loci in type 1 diabetes."xsd:string |
http://purl.uniprot.org/citations/18426861 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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