| http://purl.uniprot.org/citations/18428028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18428028 | http://www.w3.org/2000/01/rdf-schema#comment | "IGF-II plays a crucial role in fetal and cancer development by signaling through the IGF-I receptor. We have shown that inhibition of IGF-II by resveratrol (RSV) induced apoptosis and that proIGF-II (highly expressed in cancer) was more potent than mIGF-II in inhibiting this effect. Thus, we hypothesized that IGF-II differentially regulates the signaling cascade of the IGF-I receptor to stimulate the anti-apoptotic proteins Bcl-2 and Bcl-X(L) to prevent apoptosis. RSV treatment to breast cancer cells inhibited Bcl-2 and Bcl-X(L) expression and induced mitochondrial membrane depolarization. ProIGF-II was more potent than mIGF-II in: (1) activating the PI3/Akt pathway, (2) regulating Bcl-2 and Bcl-X(L) expression, and (3) inducing phosphorylation/nuclear translocation of Cyclic AMP-responsive element binding protein. Furthermore, IGF-II differentially regulated the intracellular translocation of Bcl-2 and Bcl-X(L), a critical process in breast cancer progression to hormone-independence. Our study provides a novel mechanism of how proIGF-II promotes progression and chemoresistance in breast cancer development."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.org/dc/terms/identifier | "doi:10.1080/08977190802057258"xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/author | "Singh S.K."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/author | "De Leon D.D."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/author | "De Leon M."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/author | "Almaguel F."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/author | "Moretta D."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/pages | "92-103"xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/title | "Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/18428028 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18428028 |
| http://purl.uniprot.org/citations/18428028 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18428028 |
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| http://purl.uniprot.org/uniprot/#_Q07817-mappedCitation-18428028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18428028 |
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| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ8-mappedCitation-18428028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18428028 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQR6-mappedCitation-18428028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18428028 |
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| http://purl.uniprot.org/uniprot/#_A9QXG9-mappedCitation-18428028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18428028 |