| http://purl.uniprot.org/citations/18430927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18430927 | http://www.w3.org/2000/01/rdf-schema#comment | "The four mammalian MutL homologs (MLH1, MLH3, PMS1, and PMS2) participate in a variety of events, including postreplicative DNA repair, prevention of homeologous recombination, and crossover formation during meiosis. In this latter role, MLH1-MLH3 heterodimers predominate and are essential for prophase I progression. Previous studies demonstrated that mice lacking Mlh1 exhibit a 90% reduction in crossing over at the Psmb9 hot spot while noncrossovers, which do not result in exchange of flanking markers but arise from the same double-strand break event, are unaffected. Using a PCR-based strategy that allows for detailed analysis of crossovers and noncrossovers, we show here that Mlh3(-/-) exhibit a 85-94% reduction in the number of crossovers at the Psmb9 hot spot. Most of the remaining crossovers in Mlh3(-/-) meiocytes represent simple exchanges similar to those seen in wild-type mice, with a small fraction (6%) representing complex events that can extend far from the initiation zone. Interestingly, we detect an increase of noncrossovers in Mlh3(-/-) spermatocytes. These results suggest that MLH3 functions predominantly with MLH1 to promote crossovers, while noncrossover events do not require these activities. Furthermore, these results indicate that approximately 10% of crossovers in the mouse are independent of MLH3, suggesting the existence of alternative crossover pathways in mammals."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.084798"xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/author | "de Massy B."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/author | "Cohen P.E."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/author | "Baudat F."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/author | "Svetlanov A."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/pages | "1937-1945"xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/title | "Distinct functions of MLH3 at recombination hot spots in the mouse."xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/18430927 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18430927 |
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| http://purl.uniprot.org/uniprot/#_O43196-mappedCitation-18430927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18430927 |
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| http://purl.uniprot.org/uniprot/#_P11802-mappedCitation-18430927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18430927 |