| http://purl.uniprot.org/citations/18433871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18433871 | http://www.w3.org/2000/01/rdf-schema#comment | "Rearrangement analysis of immunoglobulin genes is an exceptional opportunity to look back at the B lymphocyte differentiation during ontogeny and the subsequent immune response, and thus to study the selective pressures involved in autoimmune disorders. In a recent study to characterize the antigenic specificity of B lymphocytes during T1D progression, we generated hybridomas of islet-infiltrating B lymphocytes from NOD mice and other related strains developing insulitis, but with different degrees of susceptibility to T1D. We found that a sizable proportion of hybridomas produced monoclonal antibodies reactive to peripherin, an intermediate filament protein mainly found in the peripheral nervous system. Moreover, we found that anti-peripherin antibody-producing hybridomas originated from B lymphocytes that had undergone immunoglobulin class switch recombination, a characteristic of secondary immune response. Therefore, in the present study we performed immunoglobulin VL and VH analysis of these hybridomas to ascertain whether they were derived from B lymphocytes that had undergone antigen-driven selection. The results indicated that whereas some anti-peripherin hybridomas showed signs of oligoclonality, somatic hypermutation and/or secondary rearrangements (receptor edition and receptor revision), others seemed to directly derive from the preimmune repertoire. In view of these results, we conclude that anti-peripherin B lymphocytes are positively selected and primed in the course of T1D development in NOD mice, and reinforce the idea that peripherin is a relevant autoantigen targeted during T1D development in this animal model."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2008.03.003"xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Alba A."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Stratmann T."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Carrillo J."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Pujol-Borrell R."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Planas R."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Puertas M.C."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Verdaguer J."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Pastor X."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Vives-Pi M."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/author | "Ampudia R.M."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/pages | "3152-3162"xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/title | "Anti-peripherin B lymphocytes are positively selected during diabetogenesis."xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/18433871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18433871 |
| http://purl.uniprot.org/citations/18433871 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18433871 |
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| http://purl.uniprot.org/uniprot/#_G5E846-mappedCitation-18433871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18433871 |
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