| http://purl.uniprot.org/citations/18434321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18434321 | http://www.w3.org/2000/01/rdf-schema#comment | "The hypoxia-inducible transcription factors (HIF)-1alpha and -2alpha mediate responses to hypoxia, such as tumor neovascularization. To determine the function of HIF-2alpha in vascular endothelial cells (ECs), we examined vascular formation in HIF-2alpha knockdown (kd/kd) mice transplanted with tumors. We observed that both the tumor size and the number of large vessels growing within transplanted melanomas were significantly reduced in kd/kd recipients compared with wild-type (WT) mice. In contrast, we observed a similar extent of vascular formation within fibrosarcomas transplanted from either kd/kd or WT mice into WT recipients. Thus, HIF-2alpha expression in host animal ECs, but not in the tumor cells, is crucial for tumor neovascularization. HIF-2alpha may function through ephrin A1 as the expression of ephrin A1 and related genes was markedly reduced in kd/kd ECs, and HIF-2alpha specifically bound a hypoxia-response element sequence in the ephrin A1 promoter. Treatment of WT ECs with an ephrin A1 inhibitor (ephrin A1-Fc) also impaired neovascularization. We conclude that in ECs, HIF-2alpha plays an essential role in vascular remodeling during tumor vascularization through activation of at least ephrin A1."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m709133200"xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Miwa Y."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Nagano M."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Kaneko N."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Fujii-Kuriyama Y."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Ohneda K."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Ohneda O."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/author | "Miyoshi C."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/pages | "18926-18936"xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/title | "Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1."xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18434321 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18434321 |
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| http://purl.uniprot.org/uniprot/#_P97481-mappedCitation-18434321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18434321 |
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| http://purl.uniprot.org/uniprot/#_Q9D7K8-mappedCitation-18434321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18434321 |