| http://purl.uniprot.org/citations/18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18436530 | http://www.w3.org/2000/01/rdf-schema#comment | "AMP-activated protein kinase (AMPK) plays a crucial role in both cellular and whole body energy homeostasis. Here we demonstrate that the muscarinic receptor agonist carbachol activates AMPKalpha1-containing complexes in the human SH-SY5Y cell line via a mechanism specific for the AMPK upstream kinase, Ca(2+)/calmodulin-dependent protein kinase kinase beta. Activation of AMPK inhibits mRNA expression of the orexigenic neuropeptides Agouti-related peptide and melanin-concentrating hormone but surprisingly has no effect on neuropeptide Y mRNA, a neuropeptide previously shown to be regulated by AMPK. Rather than restoring mRNA levels to baseline, pharmacological inhibition of Ca(2+)/calmodulin-dependent protein kinase kinase beta or AMPK greatly increases Agouti-related peptide and melanin-concentrating hormone mRNA expression. These data support a hypothesis that modulating basal AMPK activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake."xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708987200"xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/author | "Carling D."xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/author | "Thornton C."xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/author | "Sardini A."xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/pages | "17116-17122"xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/title | "Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression."xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18436530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18436530 |
| http://purl.uniprot.org/citations/18436530 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18436530 |
| http://purl.uniprot.org/uniprot/#_B2R6A0-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/#_B4DV02-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/#_B4DVP2-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/#_Q8IZW1-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/#_Q96RR4-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/#_Q9Y478-mappedCitation-18436530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/Q96RR4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/Q9Y478 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/B4DV02 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/B2R6A0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/B4DVP2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |
| http://purl.uniprot.org/uniprot/Q8IZW1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18436530 |