| http://purl.uniprot.org/citations/18438409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18438409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18438409 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcineurin is required for B cell receptor (BCR)-induced proliferation of mature B cells. Paradoxically, loss of NFAT transcription factors, themselves calcineurin targets, induces hyperactivity, which suggests that calcineurin targets other than NFAT are required for BCR-induced proliferation. Here we demonstrate a function for the calcineurin-regulated transcription factor Mef2c in B cells. BCR-induced calcium mobilization was intact after Mef2c deletion, but loss of Mef2c caused defects in B cell proliferation and survival after BCR stimulation in vitro and lower T cell-dependent antibody responses and germinal center formation in vivo. Mef2c activity was specific to BCR stimulation, as Toll-like receptor and CD40 signaling induced normal responses in Mef2c-deficient B cells. Mef2c-dependent targets included the genes encoding cyclin D2 and the prosurvival factor Bcl-x(L). Our results emphasize an unrecognized but critical function for Mef2c in BCR signaling."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1609"xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1609"xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Nakagawa O."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Nakagawa O."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Albring J.C."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Albring J.C."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Kohyama M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Kohyama M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Sandau M.M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Sandau M.M."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Schwarz J.J."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Schwarz J.J."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Wilker P.R."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/author | "Wilker P.R."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/pages | "603-612"xsd:string |
| http://purl.uniprot.org/citations/18438409 | http://purl.uniprot.org/core/pages | "603-612"xsd:string |