| http://purl.uniprot.org/citations/18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18438411 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the IRAK family of kinases mediate Toll-like receptor (TLR) signaling. Here we show that IRAK2 was essential for sustaining TLR-induced expression of genes encoding cytokines and activation of the transcription factor NF-kappaB, despite the fact that IRAK2 was dispensable for activation of the initial signaling cascades. IRAK2 was activated 'downstream' of IRAK4, like IRAK1, and TLR-induced cytokine production was abrogated in the absence of both IRAK1 and IRAK2. Whereas the kinase activity of IRAK1 decreased within 1 h of TLR2 stimulation, coincident with IRAK1 degradation, the kinase activity of IRAK2 was sustained and peaked at 8 h after stimulation. Thus, IRAK2 is critical in late-phase TLR responses, and IRAK1 and IRAK2 are essential for the initial responses to TLR stimulation."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1606"xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Matsushita K."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Matsui K."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Saitoh T."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Kumagai Y."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/author | "Kawagoe T."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/pages | "684-691"xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/title | "Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2."xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18438411 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18438411 |
| http://purl.uniprot.org/citations/18438411 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18438411 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUW3-mappedCitation-18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18438411 |
| http://purl.uniprot.org/uniprot/#_F7CUT1-mappedCitation-18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18438411 |
| http://purl.uniprot.org/uniprot/#_B1AUV9-mappedCitation-18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18438411 |
| http://purl.uniprot.org/uniprot/#_B1AUW1-mappedCitation-18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18438411 |
| http://purl.uniprot.org/uniprot/#_B1AUW6-mappedCitation-18438411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18438411 |