| http://purl.uniprot.org/citations/18438430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18438430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18438430 | http://www.w3.org/2000/01/rdf-schema#comment | "Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c-Myc in tumorigenesis, the mechanism underlying the synergism is still not well understood. Overexpression of Pim-1/Pim-2 kinase dramatically stabilizes c-Myc in vivo, and the stabilization is partially mediated by phosphorylation of c-Myc by Pim kinase on a novel site, Ser329. We provide evidence that Pim-2 is more efficient in directly phosphorylating c-Myc Ser329 to stabilize c-Myc. In contrast, we find that Pim-1 is more effective in mediating a decrease in c-Myc Thr58 phosphorylation and an increase in c-Myc Ser62 phosphorylation than in phosphorylating Ser329. In either case, through stabilizing c-Myc, Pim-1/Pim-2 kinases enhance the transcriptional activity of c-Myc. Also knocking down either Pim-1 or Pim-2 dramatically decreases the endogenous levels of c-Myc and thus, its transcriptional activity. Finally, coexpression of the Pim kinases and c-Myc enhances the transforming activity of c-Myc as does the phosphomimic mutant of c-Myc on Ser329. We conclude that these findings appear to explain at least in part the mechanism underlying the synergism between the Pim kinases and c-Myc in tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.123"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.123"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Magnuson N.S."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/author | "Magnuson N.S."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/pages | "4809-4819"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/pages | "4809-4819"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/title | "Pim kinase-dependent inhibition of c-Myc degradation."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/title | "Pim kinase-dependent inhibition of c-Myc degradation."xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18438430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18438430 |
| http://purl.uniprot.org/citations/18438430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18438430 |