| http://purl.uniprot.org/citations/18444945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18444945 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal transplant outcomes exhibit large inter-individual variability, possibly on account of genetic variation in immune-response mediators and genes influencing the pharmacodynamics/pharmacokinetics of immunosuppressants. We examined 21 polymorphisms from 10 genes in 237 de novo renal transplant recipients participating in an open-label, multicenter study [Cyclosporine Avoidance Eliminates Serious Adverse Renal-toxicity (CAESAR)] investigating renal function and biopsy-proven acute rejection (BPAR) with different cyclosporine A regimens and mycophenolate mofetil. Genes were selected for their immune response and pharmacodynamic/pharmacokinetic relevance and were tested for association with BPAR. Four polymorphisms were significantly associated with BPAR. The ABCB1 2677T allele tripled the odds of developing BPAR (OR: 3.16, 95% CI [1.50-6.67]; P=0.003), as did the presence of at least one IMPDH2 3757C allele (OR: 3.39, 95% CI [1.42-8.09]; P=0.006). BPAR was almost fivefold more likely in patients homozygous for IL-10 -592A (OR: 4.71, 95% CI [1.52-14.55]; P=0.007) and twice as likely in patients with at least one A allele of TNF-alpha G-308A (OR: 2.18, 95% CI [1.08-4.41]; P=0.029). There were no statistically significant interactions between polymorphisms, or the different treatment regimens. Variation in genes of immune response and pharmacodynamic/pharmacokinetic relevance may be important in understanding acute rejection after renal transplant."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-2277.2008.00679.x"xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Lindpaintner K."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Spleiss O."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Vanrenterghem Y."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Essioux L."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Truman M."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Grinyo J."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Ekberg H."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Nashan B."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Vincenti F."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Voulgari A."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Nasmyth-Miller C."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/author | "Rashford M."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/name | "Transpl Int"xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/pages | "879-891"xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/title | "Association of four DNA polymorphisms with acute rejection after kidney transplantation."xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/18444945 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18444945 |
| http://purl.uniprot.org/citations/18444945 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18444945 |
| http://purl.uniprot.org/uniprot/#_F4ZUY5-mappedCitation-18444945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18444945 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-18444945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18444945 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-18444945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18444945 |