| http://purl.uniprot.org/citations/18445004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18445004 | http://www.w3.org/2000/01/rdf-schema#comment | "GATA-3 is the master transcription factor for T helper 2 (Th2) cell differentiation and is critical for the expression of Th2 cytokines. Little is known, however, about the nature of the functional molecular complexes of GATA-3. We identified a high-mobility group (HMG)-box type transcription factor, lymphoid enhancer factor 1 (LEF-1), in the GATA-3 complex present in Th2 cells using a Flag-calmodulin-binding peptide (CBP)-tag based proteomics method. The interaction between GATA-3 and LEF-1 was confirmed by co-immunoprecipitation experiments using LEF-1-introduced T-cell lineage TG40 cells. The HMG-box domain of LEF-1 and two zinc finger domains of GATA-3 were found to be important for the physical association. The introduction of LEF-1 into developing Th2 cells resulted in the suppression of Th2 cytokine production. The suppression was significantly lower in the cells into which a HMG-box-deleted LEF-1 mutant was introduced. Moreover, LEF-1 inhibited the binding activity of GATA-3 to the interleukin (IL)-5 promoter. These results suggest that LEF-1 is involved in the GATA-3 complex, while also regulating the GATA-3 function, such as the induction of Th2 cytokine expression via the inhibition of the DNA-binding activity of GATA-3."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2008.02854.x"xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Hasegawa A."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Nakayama T."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Yamashita M."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Hosokawa H."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Watarai H."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/author | "Hossain M.B."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/pages | "377-386"xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/title | "Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells."xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/18445004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18445004 |
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