| http://purl.uniprot.org/citations/18453575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18453575 | http://www.w3.org/2000/01/rdf-schema#comment | "Costimulatory ligands CD80 and CD86 have different binding preferences and affinities to their receptors, CD28 and CTLA-4. Earlier, we demonstrated that CD80 binds to CTLA-4 with higher affinity and has a role in suppressing T cell response. The current study demonstrates that not only did blockade of CD86 upon Ag presentation by bone marrow-derived dendritic cells (DC) to OVA-specific T cells result in induction of hyporesponsive T cells but also that these T cells could suppress the proliferative response of effector T cells. These T cells showed TGF-beta1 on their surface and secreted TGF-beta1 and IL-10 upon restimulation. Although blockade of CTLA-4 and neutralization of IL-10 profoundly inhibited the induction of these TGF-beta1(+) T cells, their ability to suppress the effector T cell proliferation was abrogated by neutralization of TGF-beta1 alone. Induction of TGF-beta1(+) and IL-10(+) T cells was found to be independent of natural CD4(+)CD25(+) regulatory T cells, demonstrating that preferential ligation of CTLA-4 by CD80 induced IL-10 production by effector T cells, which in turn promoted the secretion of TGF-beta1. Treatment of prediabetic NOD mice with islet beta cell Ag-pulsed CD86(-/-) DCs, but not CD80(-/-) DCs, resulted in the induction of TGF-beta1- and IL-10-producing cells, significant suppression of insulitis, and delay of the onset of hyperglycemia. These observations demonstrate not only that CD80 preferentially binds to CTLA-4 but also that interaction during Ag presentation can result in IL-10-dependent TGF-beta1(+) regulatory T cell induction, reinstating the potential of approaches to preferentially engage CTLA-4 through CD80 during self-Ag presentation in suppressing autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.10.6566"xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Holterman M.J."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Vasu C."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Prabhakar B.S."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Perez N."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/author | "Karumuthil-Melethil S."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/pages | "6566-6576"xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/title | "Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation."xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18453575 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18453575 |
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