| http://purl.uniprot.org/citations/18455126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18455126 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that Mll-AF9, when under endogenous regulatory control, efficiently transformed LSK (Lin(-)Sca1(+)c-kit(+)) stem cells, while committed granulocyte-monocyte progenitors (GMPs) were transformation resistant and did not cause leukemia. Mll-AF9 was expressed at higher levels in hematopoietic stem (HSC) than GMP cells. Mll-AF9 gene dosage effects were directly shown in experiments where GMPs were efficiently transformed by the high dosage of Mll-AF9 resulting from retroviral transduction. Mll-AF9 upregulated expression of 192 genes in both LSK and progenitor cells, but to higher levels in LSKs than in committed myeloid progenitors."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.03.005"xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Sam T.N."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Kersey J.H."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Hudson W.A."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Kumar A.R."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Lund E.A."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/author | "Staggs R.A."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/pages | "432-440"xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/title | "Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells."xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18455126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18455126 |
| http://purl.uniprot.org/citations/18455126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18455126 |
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| http://purl.uniprot.org/uniprot/#_Q5DTR3-mappedCitation-18455126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18455126 |
| http://purl.uniprot.org/uniprot/#_S4R2S5-mappedCitation-18455126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18455126 |