| http://purl.uniprot.org/citations/18455987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18455987 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium/calmodulin (Ca2+/CaM)-dependent protein kinase II (CaMKII) couples increases in cellular Ca2+ to fundamental responses in excitable cells. CaMKII was identified over 20 years ago by activation dependence on Ca2+/CaM, but recent evidence shows that CaMKII activity is also enhanced by pro-oxidant conditions. Here we show that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM. CaMKII is activated by angiotensin II (AngII)-induced oxidation, leading to apoptosis in cardiomyocytes both in vitro and in vivo. CaMKII oxidation is reversed by methionine sulfoxide reductase A (MsrA), and MsrA-/-mice show exaggerated CaMKII oxidation and myocardial apoptosis, impaired cardiac function, and increased mortality after myocardial infarction. Our data demonstrate a dynamic mechanism for CaMKII activation by oxidation and highlight the critical importance of oxidation-dependent CaMKII activation to AngII and ischemic myocardial apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.02.048"xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Colbran R.J."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Guan X."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "O'Donnell S.E."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Anderson M.E."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Mohler P.J."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Spitz D.R."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Zimmerman K."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Bartlett R.K."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Weiss R.M."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Erickson J.R."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Ham A.J."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Joiner M.L."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Shea M.A."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Kutschke W."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Zimmerman M.C."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Aykin-Burns N."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Oddis C.V."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/author | "Lowe J.S."xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/18455987 | http://purl.uniprot.org/core/pages | "462-474"xsd:string |