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| http://purl.uniprot.org/citations/18457952 | http://www.w3.org/2000/01/rdf-schema#comment | "Many fungi grow over a wide pH range and their gene expression is tailored to the environmental pH. In Aspergillus nidulans, the transcription factor PacC, an activator of genes expressed in alkaline conditions and a repressor of those expressed in acidic conditions, undergoes two processing proteolyses, the first being pH-signal dependent and the second proteasomal. Signal transduction involves a 'go-between' connecting two complexes, one of which comprises two plasma membrane proteins and an arrestin and the other comprises PacC, a cysteine protease, a scaffold and endosomal components. The Saccharomyces cerevisiae PacC orthologue, Rim101p, differs in that it does not undergo the second round of proteolysis and it functions directly as a repressor only. PacC/Rim101-mediated pH regulation is crucial to fungal pathogenicity."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tim.2008.03.006"xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/author | "Bignell E."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/author | "Penalva M.A."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/author | "Arst H.N. Jr."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/author | "Tilburn J."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/name | "Trends Microbiol"xsd:string |
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| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/title | "Ambient pH gene regulation in fungi: making connections."xsd:string |
| http://purl.uniprot.org/citations/18457952 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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