| http://purl.uniprot.org/citations/18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18458347 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells regulate various immune responses by exerting cytotoxic activity or secreting cytokines. The interaction of NK cells with dendritic cells (DC) contributes to NK cell-mediated antitumor or antimicrobial responses. However, the cellular and molecular mechanisms for controlling this interaction are largely unknown. Here, we show an involvement of Jagged2-Notch interaction in augmenting NK cell cytotoxicity mediated by DC. Enforced expression of Jagged2 on A20 cells (Jag2-A20 cells) suppressed their growth in vivo, which was abrogated by depleting NK cells. Moreover, Jag2-A20 cells exerted a suppression on the growth of nonmanipulated A20 cells in SCID mice in an NK-dependent manner. Consistently, coinoculation of A20 cells with DC overexpressing Jagged2 (Jag2-DC) suppressed the growth of A20 cells in mice. Stimulation of NK cells with Jagged2 directly enhanced their cytotoxicity, IFN-gamma production, and proliferation. Ligation of Notch2 on NK cells enhanced their cytotoxic activity, and Jag2-DC or CpG-treated DC-mediated NK cell cytotoxicity was suppressed by a gamma-secretase inhibitor. These results indicate that the Jagged2-Notch axis plays a crucial role in DC-mediated NK cell cytotoxicity. Furthermore, manipulation of this interaction may provide an approach to induce potent tumor immunity or to inhibit certain autoimmune diseases caused by NK cell activation."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709919105"xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Yamaguchi T."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Shimada M."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Maekawa Y."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Yasutomo K."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Koyanagi A."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Kijima M."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/author | "Ishifune C."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/pages | "7010-7015"xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/title | "Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction."xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18458347 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18458347 |
| http://purl.uniprot.org/citations/18458347 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18458347 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VLS8-mappedCitation-18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18458347 |
| http://purl.uniprot.org/uniprot/#_A2AIX5-mappedCitation-18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18458347 |
| http://purl.uniprot.org/uniprot/#_O35516-mappedCitation-18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18458347 |
| http://purl.uniprot.org/uniprot/#_O55138-mappedCitation-18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18458347 |
| http://purl.uniprot.org/uniprot/#_Q921Z7-mappedCitation-18458347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18458347 |