| http://purl.uniprot.org/citations/18459962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18459962 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases are suggested to play essential roles not only in apoptotic but also in non-apoptotic functions. However, the contribution of caspases to the cell cycle regulation is unclear. Here we found that caspases including caspase-3, caspase-7, caspase-8 and caspase-9 were activated during mitosis. Chemically synthesized caspase inhibitors delayed mitotic progression and induced accumulation of mitotic cells, which exhibited abnormal chromatin condensation and incomplete chromosome segregation. Furthermore, knockdown of caspase-7 by using small interfering RNAs resulted in the inhibition of cell proliferation, but knockdown of other caspases did not show a significant effect on cell growth. The expression of short hairpin RNA directed against caspase-7 induced the cell cycle arrest at mitosis, which was rescued by the re-expression of caspase-7 containing silent mutations at the target site for the short hairpin RNA. These results revealed that caspase-7 has a novel role during cell cycle progression at mitosis."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2008.01192.x"xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/author | "Hashimoto T."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/author | "Hunter T."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/author | "Kikkawa U."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/author | "Kamada S."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/author | "Yamauchi L."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/pages | "609-621"xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/title | "Possible involvement of caspase-7 in cell cycle progression at mitosis."xsd:string |
| http://purl.uniprot.org/citations/18459962 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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