| http://purl.uniprot.org/citations/18462684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18462684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18462684 | http://www.w3.org/2000/01/rdf-schema#comment | "The phosphorylation of IkappaB by the IKK complex targets it for degradation and releases NF-kappaB for translocation into the nucleus to initiate the inflammatory response, cell proliferation, or cell differentiation. The IKK complex is composed of the catalytic IKKalpha/beta kinases and a regulatory protein, NF-kappaB essential modulator (NEMO; IKKgamma). NEMO associates with the unphosphorylated IKK kinase C termini and activates the IKK complex's catalytic activity. However, detailed structural information about the NEMO/IKK interaction is lacking. In this study, we have identified the minimal requirements for NEMO and IKK kinase association using a variety of biophysical techniques and have solved two crystal structures of the minimal NEMO/IKK kinase associating domains. We demonstrate that the NEMO core domain is a dimer that binds two IKK fragments and identify energetic hot spots that can be exploited to inhibit IKK complex formation with a therapeutic agent."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2008.02.012"xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2008.02.012"xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Cheung A."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Cheung A."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Berkowitz S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Berkowitz S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Bixler S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Bixler S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Bowes S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Bowes S."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Cuervo H."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Cuervo H."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Guckian K."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Guckian K."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Lugovskoy A."xsd:string |
| http://purl.uniprot.org/citations/18462684 | http://purl.uniprot.org/core/author | "Lugovskoy A."xsd:string |