| http://purl.uniprot.org/citations/18463631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18463631 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes. These join Argonaute-1 to regulate gene expression. A second endogenous small RNA class, the Piwi-interacting RNAs, bind Piwi proteins and suppress transposons. Piwi-interacting RNAs are restricted to the gonad, and at least a subset of these arises by Piwi-catalysed cleavage of single-stranded RNAs. Here we show that Drosophila generates a third small RNA class, endogenous small interfering RNAs, in both gonadal and somatic tissues. Production of these RNAs requires Dicer-2, but a subset depends preferentially on Loquacious rather than the canonical Dicer-2 partner, R2D2 (ref. 14). Endogenous small interfering RNAs arise both from convergent transcription units and from structured genomic loci in a tissue-specific fashion. They predominantly join Argonaute-2 and have the capacity, as a class, to target both protein-coding genes and mobile elements. These observations expand the repertoire of small RNAs in Drosophila, adding a class that blurs distinctions based on known biogenesis mechanisms and functional roles."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07007"xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Dus M."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Stark A."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Zhou R."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Wohlschlegel J.A."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Hannon G.J."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Kellis M."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Sachidanandam R."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Brennecke J."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Czech B."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Malone C.D."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/author | "Schlingeheyde C."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/pages | "798-802"xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/title | "An endogenous small interfering RNA pathway in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://purl.uniprot.org/core/volume | "453"xsd:string |
| http://purl.uniprot.org/citations/18463631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18463631 |
| http://purl.uniprot.org/citations/18463631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18463631 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI70-mappedCitation-18463631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18463631 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFK8-mappedCitation-18463631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18463631 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCY2-mappedCitation-18463631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18463631 |