| http://purl.uniprot.org/citations/1846560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1846560 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA strand cleavage reaction catalyzed by endonuclease III from Escherichia coli (endo III) on the 3'-side of aldehyde abasic sites proceeds by a syn beta-elimination involving abstraction of the 2'-pro-S proton and formation of a trans alpha,beta-unsaturated aldose product; we previously reported the same stereochemical course for the reaction catalyzed by UV endonuclease V from bacteriophage T4 (UV endo V) [Mazumder, A., Gerlt, J. A., Rabow, L., Absalon, M. J., Stubbe, J., & Bolton, P. H. (1989) J. Am. Chem. Soc. 111, 8029-8030]. Since the UV endo V does not contain an 4Fe-4S center, the 4Fe-4S center present in endo III need not be assigned a unique role in the beta-elimination reaction. The beta-elimination reactions that occur under alkaline conditions (0.1 N NaOH) and in the presence of the tripeptide Lys-Trp-Lys proceed by anti beta-elimination mechanisms involving abstraction of the 2'-pro-R proton and formation of a trans alpha,beta-unsaturated aldose product. The different stereochemical outcomes of the enzymatic and nonenzymatic beta-elimination reactions support the hypothesis that the enzyme-catalyzed reactions may involve general-base-catalyzed abstraction of the 2'-pro-S proton by the internucleotidic phosphodiester leaving group."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00218a033"xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Gerlt J.A."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Cunningham R.P."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Stubbe J."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Bolton P.H."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Mazumder A."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Absalon M.J."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/author | "Withka J."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/pages | "1119-1126"xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/title | "Stereochemical studies of the beta-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys."xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/1846560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1846560 |
| http://purl.uniprot.org/citations/1846560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1846560 |
| http://purl.uniprot.org/uniprot/P0AB83#attribution-E7B629C4EB86C2E9C2F7157033297484 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1846560 |