http://purl.uniprot.org/citations/18466483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18466483 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present paper, we used the North American Rheumatoid Arthritis Consortium data provided for Genetic Analysis Workshop 15 Problem 2 to: 1) estimate the penetrances of PTPN22 and HLA-DRB1 and, 2) test the selected model of PTPN22 conditional on the rheumatoid factor status. To achieve these aims, we used the marker association segregation chi-square method, fitting simultaneously both genotype frequency and identical by descent distributions in a sample of 3690 White individuals from 604 nuclear families. A co-dominant model fitted the rs2476601 (R620W) single-nucleotide polymorphism (SNP) of the PTPN22 gene well, whereas a lack of fit for all models was observed for the HLA-DRB1 locus. Testing genetic models of rheumatoid arthritis that include the PTPN22 SNP in addition to the HLA-DRB1 locus did not affect the results, nor did subgroup analysis of PTPN22 conditional on the rheumatoid factor status. In conclusion, PTPN22 R620W SNP is a risk factor for rheumatoid arthritis. The genetic architecture of the HLA-DRB1 locus is highly complex, and more elaborate modeling of this locus is required."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.org/dc/terms/identifier | "doi:10.1186/1753-6561-1-s1-s14"xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/author | "Tezenas du Montcel S."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/author | "Plancoulaine S."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/author | "Gagnon F."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/author | "Hajage D."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/name | "BMC Proc 1 Suppl"xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/pages | "S14"xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/title | "Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis."xsd:string |
http://purl.uniprot.org/citations/18466483 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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