| http://purl.uniprot.org/citations/18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18467503 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-beta is an important regulator of growth and differentiation in the pancreas and has been implicated in pancreatic tumorigenesis. We have recently demonstrated that TGF-beta can activate protein kinase A (PKA) in mink lung epithelial cells (Zhang L, Duan C, Binkley C, Li G, Uhler M, Logsdon C, Simeone D. Mol Cell Biol 24: 2169-2180, 2004). In this study, we sought to determine whether TGF-beta activates PKA in pancreatic acinar cells, the mechanism by which PKA is activated, and PKA's role in TGF-beta-mediated growth regulatory responses. TGF-beta rapidly activated PKA in pancreatic acini while having no effect on intracellular cAMP levels. Coimmunoprecipitation experiments demonstrated a physical interaction between a Smad3/Smad4 complex and the regulatory subunits of PKA. TGF-beta also induced activation of the PKA-dependent transcription factor CREB. Both the specific PKA inhibitor H89 and PKI peptide significantly blocked TGF-beta's ability to activate PKA and CREB. TGF-beta-mediated growth inhibition and TGF-beta-induced p21 and SnoN expression in pancreatic acinar cells were blocked by H89 and PKI peptide. This study demonstrates that this novel cross talk between TGF-beta and PKA signaling pathways may play an important role in regulating TGF-beta signaling in the pancreas."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00492.2007"xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/author | "Lee C.J."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/author | "Sans M.D."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/author | "Simeone D.M."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/pages | "G170-G178"xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/title | "Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells."xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://purl.uniprot.org/core/volume | "295"xsd:string |
| http://purl.uniprot.org/citations/18467503 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18467503 |
| http://purl.uniprot.org/citations/18467503 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18467503 |
| http://purl.uniprot.org/uniprot/#_D3Z7C5-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_D3YYG2-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_E9PZB1-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VKM7-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_F6U840-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_J9JDU9-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_E9PWM8-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_E9PYW2-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |
| http://purl.uniprot.org/uniprot/#_E9PZ49-mappedCitation-18467503 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18467503 |