| http://purl.uniprot.org/citations/18469803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18469803 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite intense investigation, mechanisms that facilitate the emergence of the pre-eclampsia phenotype in women are still unknown. Placental hypoxia, hypertension, proteinuria and oedema are the principal clinical features of this disease. It is speculated that hypoxia-driven disruption of the angiogenic balance involving vascular endothelial growth factor (VEGF)/placenta-derived growth factor (PLGF) and soluble Fms-like tyrosine kinase-1 (sFLT-1, the soluble form of VEGF receptor 1) might contribute to some of the maternal symptoms of pre-eclampsia. However, pre-eclampsia does not develop in all women with high sFLT-1 or low PLGF levels, and it also occurs in some women with low sFLT-1 and high PLGF levels. Moreover, recent experiments strongly suggest that several soluble factors affecting the vasculature are probably elevated because of placental hypoxia in the pre-eclamptic women, indicating that upstream molecular defect(s) may contribute to pre-eclampsia. Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol (2-ME), a natural metabolite of oestradiol that is elevated during the third trimester of normal human pregnancy. 2-ME ameliorates all pre-eclampsia-like features without toxicity in the Comt(-/-) pregnant mice and suppresses placental hypoxia, hypoxia-inducible factor-1alpha expression and sFLT-1 elevation. The levels of COMT and 2-ME are significantly lower in women with severe pre-eclampsia. Our studies identify a genetic mouse model for pre-eclampsia and suggest that 2-ME may have utility as a plasma and urine diagnostic marker for this disease, and may also serve as a therapeutic supplement to prevent or treat this disorder."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06951"xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Xie L."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Ahmad S."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Sugimoto H."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Augustin H.G."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Hamano Y."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Folkman J."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Kalluri R."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Strauss J.F."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Parry S."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Gattone V.H."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Kanasaki K."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/author | "Palmsten K."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/pages | "1117-1121"xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/title | "Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia."xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://purl.uniprot.org/core/volume | "453"xsd:string |
| http://purl.uniprot.org/citations/18469803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18469803 |
| http://purl.uniprot.org/citations/18469803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18469803 |
| http://purl.uniprot.org/uniprot/#_D3Z782-mappedCitation-18469803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18469803 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP63-mappedCitation-18469803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18469803 |
| http://purl.uniprot.org/uniprot/#_A0A140VJG8-mappedCitation-18469803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18469803 |