| http://purl.uniprot.org/citations/18469807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18469807 | http://www.w3.org/2000/01/rdf-schema#comment | "Netrins, a family of secreted molecules, have critical functions in axon guidance and cell migration during neuronal development. In addition to its role as a chemotropic molecule, netrin-1 also acts as a survival factor. Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9). In the absence of netrin-1, DCC and UNC5 act as dependence receptors and trigger apoptosis. However, how netrin-1 suppresses the apoptotic activity of the receptors remains elusive. Here we show that netrin-1 induces interaction of UNC5B with the brain-specific GTPase PIKE-L. This interaction triggers the activation of PtdIns-3-OH kinase signalling, prevents UNC5B's pro-apoptotic activity and enhances neuronal survival. Moreover, this process relies strongly on Fyn because PIKE-L is tyrosine phosphorylated in response to netrin-1, and the netrin-1-mediated interaction of UNC5B with PIKE-L is inhibited in Fyn-null mice. Thus, PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1732"xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Hong Y."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Jang S.W."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Luo S.W."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Xiong W.C."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Chan C.B."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/author | "Rama N."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/pages | "698-706"xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/title | "Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B."xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/18469807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18469807 |
| http://purl.uniprot.org/citations/18469807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18469807 |
| http://purl.uniprot.org/uniprot/Q8CGU4#attribution-26CF6BBFC72F2FB4DA576712102B9C02 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18469807 |
| http://purl.uniprot.org/uniprot/Q62844#attribution-26CF6BBFC72F2FB4DA576712102B9C02 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18469807 |
| http://purl.uniprot.org/uniprot/Q8IZJ1#attribution-26CF6BBFC72F2FB4DA576712102B9C02 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18469807 |