| http://purl.uniprot.org/citations/18471976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18471976 | http://www.w3.org/2000/01/rdf-schema#comment | "The p53 tumor suppressor restricts tumorigenesis through the transcriptional activation of target genes involved in cell-cycle arrest and apoptosis. Here, we identify Prl-3 (phosphatase of regenerating liver-3) as a p53-inducible gene. Whereas previous studies implicated Prl-3 in metastasis because of its overexpression in metastatic human colorectal cancer and its ability to promote invasiveness and motility, we demonstrate here that Prl-3 is an important cell-cycle regulator. Consistent with a role in DNA damage-induced cell-cycle arrest, Prl-3 overexpression induces G(1) arrest downstream of p53 by triggering a PI3K-Akt-activated negative feedback loop. Surprisingly, attenuation of Prl-3 expression also elicits an arrest response, suggesting that basal level Prl-3 expression is pivotal for normal cell-cycle progression. Our findings highlight key dose-dependent functions of Prl-3 in both positive and negative regulation of cell-cycle progression and provide insight into Prl-3's role in cancer progression."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.04.002"xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Zeng Q."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Basak S."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Kaldis P."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Giaccia A.J."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Pathak N."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Attardi L.D."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Jacobs S.B."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/author | "Krieg A.J."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/pages | "303-314"xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/title | "The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation."xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/18471976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18471976 |
| http://purl.uniprot.org/citations/18471976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18471976 |
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| http://purl.uniprot.org/uniprot/#_A5JTV6-mappedCitation-18471976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18471976 |
| http://purl.uniprot.org/uniprot/#_E9PXS4-mappedCitation-18471976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18471976 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-18471976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18471976 |