| http://purl.uniprot.org/citations/18477467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18477467 | http://www.w3.org/2000/01/rdf-schema#comment | "NEFA/nucleobindin2 (NUCB2), a novel satiety molecule, is associated with leptin-independent melanocortin signaling in the central nervous system. Here, we show that systemic administration of m-chlorophenylpiperazine (mCPP), a serotonin 5-HT1B/2C receptor agonist, significantly increased the expression of hypothalamic NUCB2 in wild-type mice. The increases in hypothalamic NUCB2 expression induced by mCPP were attenuated in 5-HT2C receptor mutant mice. Systemic administration of mCPP suppressed food intake in db/db mice with leptin receptor mutation as well as lean control mice. On the other hand, the expression of hypothalamic NUCB2 and proopiomelanocortin (POMC) was significantly decreased in hyperphagic and non-obese 5-HT2C receptor mutants compared with age-matched wild-type mice. Interestingly, despite increased expression of hypothalamic POMC, hypothalamic NUCB2 expression was decreased in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene. These findings suggest that 5-HT systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors, and induce anorexia via a leptin-independent pathway in mice."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.05.010"xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/author | "Nonogaki K."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/author | "Oka Y."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/author | "Sumii M."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/pages | "186-190"xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/title | "Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice."xsd:string |
| http://purl.uniprot.org/citations/18477467 | http://purl.uniprot.org/core/volume | "372"xsd:string |
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