| http://purl.uniprot.org/citations/18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18480060 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells with functional DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MMR-deficient cells fail to detect MNNG-induced DNA damage, resulting in the survival of "mutator" cells. The retrograde (nucleus-to-cytoplasm) signaling that initiates MMR-dependent G(2) arrest and cell death remains undefined. Since MMR-dependent phosphorylation and stabilization of p53 were noted, we investigated its role(s) in G(2) arrest and apoptosis. Loss of p53 function by E6 expression, dominant-negative p53, or stable p53 knockdown failed to prevent MMR-dependent G(2) arrest, apoptosis, or lethality. MMR-dependent c-Abl-mediated p73alpha and GADD45alpha protein up-regulation after MNNG exposure prompted us to examine c-Abl/p73alpha/GADD45alpha signaling in cell death responses. STI571 (Gleevec, a c-Abl tyrosine kinase inhibitor) and stable c-Abl, p73alpha, and GADD45alpha knockdown prevented MMR-dependent apoptosis. Interestingly, stable p73alpha knockdown blocked MMR-dependent apoptosis, but not G(2) arrest, thereby uncoupling G(2) arrest from lethality. Thus, MMR-dependent intrinsic apoptosis is p53-independent, but stimulated by hMLH1/c-Abl/p73alpha/GADD45alpha retrograde signaling."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m709954200"xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/author | "Li L.S."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/author | "Boothman D.A."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/author | "Hwang A."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/author | "Morales J.C."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/author | "Wagner M.W."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/pages | "21394-21403"xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/title | "DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18480060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18480060 |
| http://purl.uniprot.org/citations/18480060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
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| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A346XLN8-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |
| http://purl.uniprot.org/uniprot/#_A0A346XLS8-mappedCitation-18480060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18480060 |