| http://purl.uniprot.org/citations/18480061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18480061 | http://www.w3.org/2000/01/rdf-schema#comment | "Current published data suggest that DNA mismatch repair (MMR) triggers prolonged G(2) cell cycle checkpoint arrest after alkylation damage from N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by activating ATR (ataxia telangiectasia-Rad3-related kinase). However, analyses of isogenic MMR-proficient and MMR-deficient human RKO colon cancer cells revealed that although ATR/Chk1 signaling controlled G(2) arrest in MMR-deficient cells, ATR/Chk1 activation was not involved in MMR-dependent G(2) arrest. Instead, we discovered that disrupting c-Abl activity using STI571 (Gleevec, a c-Abl inhibitor) or stable c-Abl knockdown abolished MMR-dependent p73alpha stabilization, induction of GADD45alpha protein expression, and G(2) arrest. In addition, inhibition of c-Abl also increased the survival of MNNG-exposed MMR-proficient cells to a level comparable with MMR-deficient cells. Furthermore, knocking down GADD45alpha (but not p73alpha) protein levels affected MMR-dependent G(2) arrest responses. Thus, MMR-dependent G(2) arrest responses triggered by MNNG are dependent on a human MLH1/c-Abl/GADD45alpha signaling pathway and activity. Furthermore, our data suggest that caution should be taken with therapies targeting c-Abl kinase because increased survival of mutator phenotypes may be an unwanted consequence."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m709953200"xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Garner H.R."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Bornmann W.G."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Li L.S."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Boothman D.A."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Galindo C.L."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Morales J.C."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/author | "Wagner M.W."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/pages | "21382-21393"xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/title | "Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses."xsd:string |
| http://purl.uniprot.org/citations/18480061 | http://purl.uniprot.org/core/volume | "283"xsd:string |
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