| http://purl.uniprot.org/citations/18483397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18483397 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging data suggest a critical role for bone marrow angiogenesis in hematologic malignancies. The angiopoietin/Tie ligand-receptor system is an essential regulator of this process. We evaluated whether circulating angiopoietin-2 (Ang-2) is a predictor for the probability of disease-free survival (DFS) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk acute myeloid leukemia or myelodysplastic syndrome. Ang-2 was measured by enzyme-linked immunosorbent assay in serum from 20 healthy controls and 90 patients with acute myeloid leukemia or myelodysplastic syndrome before conditioning for HSCT. Circulating Ang-2 was elevated in patients (median, 2.21 ng/mL; range, 0.18-48.84 ng/mL) compared with controls (median, 0.87 ng/mL; range, 0.27-4.51 ng/mL; P < .001). Multivariate analyses confirmed the independent prognostic impact of Ang-2 (hazard ratio [HR] = 2.46; 95% confidence interval [CI], 1.27-4.76, P = .005), percentage of bone marrow infiltration (HR = 1.14; 95% CI, 1.01-1.29, P = .033), and chemotherapy cycles before HSCT (HR = 1.38; 95% CI, 1.01-1.08, P = .048). Regression tree analysis detected optimal cutoff values for Ang-2 and recursively identified bone marrow blasts and Ang-2 as the best predictors for DFS. Because few predictors for DFS exist in the setting of allo-HSCT, Ang-2 may be used as a readily available powerful biomarker to pre-estimate DFS and may open new perspectives for risk-adapted treatment of high-risk myeloid malignancies."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-12-130021"xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Eder M."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "David S."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Horn R."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Haller H."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Ganser A."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Buchholz S."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Koenecke C."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Krauter J."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Hecker H."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Verhagen W."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Hertenstein B."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Gohring G."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Kumpers P."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/author | "Hellpap J."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/pages | "2139-2148"xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/title | "Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies."xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18483397 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18483397 |
| http://purl.uniprot.org/citations/18483397 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18483397 |
| http://purl.uniprot.org/uniprot/#_B2R6E3-mappedCitation-18483397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18483397 |