| http://purl.uniprot.org/citations/18485100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18485100 | http://www.w3.org/2000/01/rdf-schema#comment | "The inhibitors of apoptosis (IAPs) are emerging as key proteins in the control of cell death. In this study, we evaluated the expression and subcellular distribution of the antiapoptotic protein X-linked IAP (XIAP), and its interactions with the XIAP-associated factor 1 (XAF1) in neonatal rat brain following hypoxia-ischemia (HI). HI triggered the mitochondrial release of cytochrome c, Smac/DIABLO, and caspase 3 activation. Confocal microscopy detected XIAP-specific immunofluorescence in the cytoplasm under normal condition, which exhibited a diffuse distribution at 6 h post-HI and by 12 h the majority of XIAP was redistributed into the nucleus. XIAP nuclear translocation was confirmed by subcellular fractionations and by expressing FLAG-tagged XIAP in primary cortical neurons. Over-expression of XIAP significantly reduced, whereas XIAP gene silencing further enhanced cell death, demonstrating a specific requirement of cytoplasmic XIAP for cell survival. An elevated level of cytosolic XIAP was also evident under the conditions of neuroprotection by fibroblast growth factor-1. XAF1 expression was increased temporally and there was increased nuclear co-localization with XIAP in hypoxic-ischemic cells. XIAP co-immunoprecipitated > 9-fold XAF1 protein concurrent with decreased association with caspases 9 and 3. This is evidenced by the enhanced caspase 3 activity and neuronal death. Our findings implicate XIAP nuclear translocation in neuronal death and point to a novel mechanism in the regulation of hypoxic-ischemic brain injury."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2008.05482.x"xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/author | "Hossain M.A."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/author | "Russell J.C."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/author | "Szuflita N."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/author | "Whiting H."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/pages | "1357-1370"xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/title | "Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain."xsd:string |
| http://purl.uniprot.org/citations/18485100 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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