| http://purl.uniprot.org/citations/18490726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18490726 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-7, a member of the common gamma-chain family of cytokines, is essential for B and T lymphocyte development and homeostasis of mature T cell subsets. Thus, naive and memory T cells are both dependent on IL-7 for survival and homeostatic proliferation under lymphopenic conditions. In line with prior findings with IL-2, we show in this study that the biological activity of IL-7 in vivo is greatly increased by association with anti-IL-7 mAb. Under in vivo conditions, IL-7/mAb complexes displayed 50-to 100-fold higher activity than free IL-7 and induced massive expansion of pre-B cells. IL-7/mAb complexes also increased thymopoiesis in normal mice and restored thymopoeisis in IL-7-deficient mice. For mature T cells, IL-7/mAb complexes induced marked homeostatic proliferation of both naive and memory CD4(+) and CD8(+) cell subsets even under normal T cell-replete conditions. Finally, IL-7/mAb complexes were able to enhance the magnitude of the primary response of Ag-specific naive CD8(+) cells. The strong stimulatory activity of IL-7/mAb complexes could be useful for treatment of immunodeficiency and cancer."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.11.7265"xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/author | "Sprent J."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/author | "Kim D.M."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/author | "Surh C.D."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/author | "Boyman O."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/author | "Ramsey C."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/pages | "7265-7275"xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/title | "IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia."xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18490726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18490726 |
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| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-18490726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18490726 |
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| http://purl.uniprot.org/uniprot/#_Q3UT18-mappedCitation-18490726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18490726 |
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