| http://purl.uniprot.org/citations/18491231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18491231 | http://www.w3.org/2000/01/rdf-schema#comment | "All-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) induce differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Here we investigated the role and regulation of death-associated protein-5 (DAP5/p97/NAT1), a novel inhibitor of translational initiation, in APL cell differentiation and apoptosis. We found that ATRA markedly induced DAP5/p97 protein and gene expression and nuclear translocation during terminal differentiation of APL (NB4) and HL60 cells but not differentiation-resistant cells (NB4.R1 and HL60R), which express very low levels of DAP5/p97. At the differentiation inducing concentrations, ATO (<0.5 microM), dimethyl sulfoxide, 1,25-dihydroxy-vitamin-D3, and phorbol-12-myristate 13-acetate also significantly induced DAP5/p97 expression in NB4 cells. However, ATO administered at apoptotic doses (1-2 microM) induced expression of DAP5/p86, a proapoptotic derivative of DAP5/p97. ATRA and ATO-induced expression of DAP5/p97 was associated with inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Furthermore, DAP5/p97 expression was upregulated by inhibition of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway via LY294002 and via rapamycin. Finally, knockdown of DAP5/p97 expression by small interfering RNA inhibited ATRA-induced granulocytic differentiation and ATO-induced apoptosis. Together, our data reveal new roles for DAP5/p97 in ATRA-induced differentiation and ATO-induced apoptosis in APL and suggest a novel regulatory mechanism by which PI3K/Akt/mTOR pathway inhibition mediates ATRA- and ATO-induced expression of DAP5/p97."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-008-0222-9"xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Lopez-Berestein G."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Ozpolat B."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Akar U."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Acevedo-Alvarez M."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Vivas-Mejia P."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/author | "Zorrilla-Calancha I."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/pages | "915-928"xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/title | "Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia."xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18491231 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18491231 |
| http://purl.uniprot.org/citations/18491231 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18491231 |
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| http://purl.uniprot.org/uniprot/#_D3DQV9-mappedCitation-18491231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18491231 |
| http://purl.uniprot.org/uniprot/#_Q2TU89-mappedCitation-18491231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18491231 |
| http://purl.uniprot.org/uniprot/#_Q3LIE0-mappedCitation-18491231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18491231 |
| http://purl.uniprot.org/uniprot/#_P78344-mappedCitation-18491231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18491231 |
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| http://purl.uniprot.org/uniprot/Q2TU89 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18491231 |
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