| http://purl.uniprot.org/citations/18492826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18492826 | http://www.w3.org/2000/01/rdf-schema#comment | "Glyceroneogenesis is an important metabolic pathway for fatty acid reesterification in adipose tissue, thereby reducing fatty acid release. Glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), which is the key enzyme in this pathway, are both regulated by a series of hormones and nutrients, among which all-trans retinoic acid (all-trans RA) is a transcriptional inducer of the PEPCK-C gene (Pck1). All-trans RA binds to the retinoic acid receptor (RAR) and activates it, whereas its stereoisomer 9-cis retinoic acid (9-cis RA) is a ligand for the 9-cis RA receptor (RXR). Three RXR-binding elements [retinoic acid response element (RARE)1/PCK1, RARE2, and RARE3/PCK2] were previously located in the promoter of Pck1. Using 3T3-F442A adipocytes, we demonstrated that Pck1 expression was 10-fold more sensitive to 9-cis RA (EC(50): 10 nmol/L) than to all-trans RA. We then analyzed the respective involvement of RARE1/PCK1, RARE2, and RARE3/PCK2 in the response of Pck1 to 9-cis RA and all-trans RA in adipocytes. The response to 9-cis RA mainly involved the RARE1/PCK1 element, whereas RARE2 was mainly responsive to all-trans RA. In contrast, the full response to both RA isomers involved these 2 elements and included RARE3/PCK2 as well. Furthermore, 9-cis RA, but not all-trans RA, selectively induced PCK1 in ex-vivo-treated human adipose tissue explants, with a concomitant induction of glyceroneogenesis monitored by [1-(14)C]-pyruvate incorporation into neutral lipids. The concomitant 9-cis RA-induced reduction in fatty acid output indicates an important role for this RA stereoisomer in lipid homeostasis through stimulation of PEPCK-C and glyceroneogenesis in adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.org/dc/terms/identifier | "doi:10.1093/jn/138.6.1004"xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Forest C."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Glorian M."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Benelli C."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Fouque F."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Cadoudal T."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/author | "Massias A."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/pages | "1004-1009"xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/title | "Retinoids upregulate phosphoenolpyruvate carboxykinase and glyceroneogenesis in human and rodent adipocytes."xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/18492826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18492826 |
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