| http://purl.uniprot.org/citations/18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18495331 | http://www.w3.org/2000/01/rdf-schema#comment | "Fanconi anemia (FA) is a heterogeneous inherited disorder characterized by a progressive bone marrow (BM) failure and susceptibility to myeloid leukemia. Genetic correction using gene-transfer technology is one potential therapy. A major hurdle in applying this technology in FA patients is the inability of granulocyte colony-stimulating factor (G-CSF) to mobilize sufficient numbers of hematopoietic stem (HSC)/progenitor cells (HPC) from the BM to the peripheral blood. Whether the low number of CD34(+) cells is a result of BM hypoplasia or an inability of G-CSF to adequately mobilize FA HSC/HPC remains incompletely understood. Here we use competitive repopulation of lethally irradiated primary and secondary recipients to show that in two murine models of FA, AMD3100 synergizes with G-CSF resulting in a mobilization of HSC, whereas G-CSF alone fails to mobilize stem cells even in the absence of hypoplasia."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exphem.2008.03.016"xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Broxmeyer H.E."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Srour E.F."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Yang F.C."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Clapp D.W."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Ciccone S.L."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Hobson M.J."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/author | "Pulliam A.C."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/name | "Exp Hematol"xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/pages | "1084-1090"xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/title | "AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice."xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/18495331 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18495331 |
| http://purl.uniprot.org/citations/18495331 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18495331 |
| http://purl.uniprot.org/uniprot/#_E9QAE8-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLC1-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |
| http://purl.uniprot.org/uniprot/#_E0CYC3-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |
| http://purl.uniprot.org/uniprot/#_E0CYI2-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |
| http://purl.uniprot.org/uniprot/#_E0CYQ7-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |
| http://purl.uniprot.org/uniprot/#_E0CYY7-mappedCitation-18495331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18495331 |