| http://purl.uniprot.org/citations/18496222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18496222 | http://www.w3.org/2000/01/rdf-schema#comment | "The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.org/dc/terms/identifier | "doi:10.1097/gim.0b013e3181770196"xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Katoh T."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Morita S."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Benhamou S."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Spitz M.R."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Roy B."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Hayes R.B."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Park K.K."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Foulkes W."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Capoluongo E."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Strange R.C."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Taioli E."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Lazarus P."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Manni J.J."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Boccia S."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Cadoni G."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Bhisey R.A."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Barros-Dios J.M."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Ruano-Ravina A."xsd:string |
| http://purl.uniprot.org/citations/18496222 | http://purl.uniprot.org/core/author | "Goloni-Bertollo E.M."xsd:string |