| http://purl.uniprot.org/citations/18498745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18498745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18498745 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent genetic studies have documented a pivotal growth-regulatory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting subunit, Skp1, and the ROC1 RING finger protein. In this report, we identified insulin receptor substrate 1 (IRS-1), a critical mediator of the insulin/insulin-like growth factor 1 signaling, as a proteolytic target of the CUL7 E3 ligase in a manner that depends on mammalian target of rapamycin and the p70 S6 kinase activities. Interestingly, while embryonic fibroblasts of Cul7-/-mice were found to accumulate IRS-1 and exhibit increased activation of IRS-1's downstream Akt and MEK/ERK pathways, these null cells grew poorly and displayed phenotypes reminiscent of those associated with oncogene-induced senescence. Taken together, our findings demonstrate a key role for the CUL7 E3 in targeting IRS-1 for degradation, a process that may contribute to the regulation of cellular senescence."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.03.009"xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.03.009"xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Tsai S.C."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Tsai S.C."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Dolios G."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Dolios G."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Pan Z.Q."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Pan Z.Q."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Field L.J."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Field L.J."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Dias-Santagata D.C."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Dias-Santagata D.C."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Lafontant P.J."xsd:string |
| http://purl.uniprot.org/citations/18498745 | http://purl.uniprot.org/core/author | "Lafontant P.J."xsd:string |