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| http://purl.uniprot.org/citations/18501702 | http://www.w3.org/2000/01/rdf-schema#comment | "The involvement of the P2 receptor in the activation of ERK induced by a short transient fluid flow stimulation in MC3T3-E1 osteoblasts was examined in the current study. The ERK activation induced by this transient fluid flow stimulation was followed by an increase in c-fos mRNA expression. Suramin, a non-selective P2 receptor antagonist, and two different P2X7 receptor (P2X7R) antagonists, ATP analogue (oxidized ATP) and dye (Brilliant blue G), inhibited fluid flow-induced ERK activation. However, the P2Y receptor pathway inhibitor U73122 did not abolish this ERK activation. The P2X7R agonist 2',3'-O-(4-benzoylbenzoyl)-ATP (BzATP) significantly increased ERK activation and this activation could be completely inhibited by oxidized ATP and Brilliant blue G. Our results suggest that P2X7R is a highly sensitive P2 receptor for fluid flow-induced ERK activation in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.05.066"xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/author | "Okumura H."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/author | "Kubo T."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/author | "Yokoyama T."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/author | "Shiba D."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/pages | "486-490"xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/title | "P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/18501702 | http://purl.uniprot.org/core/volume | "372"xsd:string |
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