| http://purl.uniprot.org/citations/18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18501717 | http://www.w3.org/2000/01/rdf-schema#comment | "The conditioned medium (CM) from mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein alpha (PI-TPalpha; SPIalpha cells) demonstrates an increased anti-apoptotic activity compared with CM from wild type NIH3T3 (wtNIH3T3) cells. As previously shown, the anti-apoptotic activity acts by activating a G protein-coupled receptor, most probably a cannabinoid 1 (CB1)-like receptor as the activity was blocked by both pertussis toxin and rimonabant [M. Schenning, C.M. van Tiel, D. Van Manen, J.C. Stam, B.M. Gadella, K.W. Wirtz and G.T. Snoek, Phosphatidylinositol transfer protein alpha regulates growth and apoptosis of NIH3T3 cells: involvement of a cannabinoid 1-like receptor, J. Lipid Res. 45 (2004) 1555-1564]. The CB1 receptor appears to be expressed in mouse fibroblast cells, at levels in the order SPIalpha>wtNIH3T3>SPIbeta cells (i.e. wild type cells overexpressing PI-TPbeta). Upon incubation of SPIbeta cells with the PI-TPalpha-dependent anti-apoptotic factors, both the ERK/MAP kinase and the Akt/PKB pathway are activated in a CB1 receptor dependent manner as shown by Western blotting. In addition, activation of ERK2 was also shown by EYFP-ERK2 translocation to the nucleus, as visualized by confocal laser scanning microscopy. The subsequent activation of the anti-apoptotic transcription factor NF-kappaB is in line with the increased resistance towards UV-induced apoptosis. On the other hand, receptor activation by CM from SPIalpha cells was not linked to phospholipase C activation as the YFP-labelled C2-domain of protein kinase C was not translocated to the plasma membrane of SPIbeta cells as visualized by confocal laser scanning microscopy."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2008.04.014"xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Schenning M."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Avram D."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Goedhart J."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Gadella T.W. Jr."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Wirtz K.W."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/author | "Snoek G.T."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/pages | "1700-1706"xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/title | "The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway."xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://purl.uniprot.org/core/volume | "1783"xsd:string |
| http://purl.uniprot.org/citations/18501717 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18501717 |
| http://purl.uniprot.org/citations/18501717 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18501717 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_A0A338P736-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_A0A338P781-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_F8WGG5-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_J3QPW1-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_J3QQ30-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_P53810-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_P53811-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |
| http://purl.uniprot.org/uniprot/#_Q922X7-mappedCitation-18501717 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501717 |