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http://purl.uniprot.org/citations/1850257http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1850257http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1850257http://www.w3.org/2000/01/rdf-schema#comment"Insulin-like growth factor binding proteins (IGFBPs) modulate the cellular action of the insulin-like growth factors. Inhibition or enhancement of IGF effects by these cell-secreted binding proteins have been described. We have purified two IGFBPs (23 and 29 kDa) from media conditioned by U-2 human osteosarcoma cells using ligand-affinity chromatography and reversed phase HPLC. N-terminal amino acid analysis of the 23 kDa protein revealed a unique sequence with variable homology to IGFBPs 1-4. The 29 kDa IGFBP was found to be nearly identical to a recently reported IGFBP. Because the affinity purified U-2 IGFBPs enhanced IGF-I-stimulated osteoblast mitogenesis, we suggest that one or both of these binding proteins enhance IGF action in bone."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.org/dc/terms/identifier"doi:10.1016/0006-291x(91)90911-p"xsd:string
http://purl.uniprot.org/citations/1850257http://purl.org/dc/terms/identifier"doi:10.1016/0006-291x(91)90911-p"xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/author"Andress D.L."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/author"Andress D.L."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/author"Birnbaum R.S."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/author"Birnbaum R.S."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/pages"213-218"xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/pages"213-218"xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/title"A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/title"A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells."xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/volume"176"xsd:string
http://purl.uniprot.org/citations/1850257http://purl.uniprot.org/core/volume"176"xsd:string
http://purl.uniprot.org/citations/1850257http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1850257
http://purl.uniprot.org/citations/1850257http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1850257
http://purl.uniprot.org/citations/1850257http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1850257
http://purl.uniprot.org/citations/1850257http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1850257
http://purl.uniprot.org/uniprot/P24592http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1850257
http://purl.uniprot.org/uniprot/P24593http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1850257