| http://purl.uniprot.org/citations/18502829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18502829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18502829 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitory killer cell immunoglobulin receptors (KIR) bind to major histocompatibility complex antigens. Concise knowledge of KIR ligands allows prediction of natural killer (NK)-cell alloreactivity after hematopoietic stem cell transplantation. KIR3DL1 binds to the Bw4 epitope on HLA-B antigens. Although the same epitope is also found on 4 HLA-A antigens (HLA-A23/24/25/32), these are not currently regarded as KIR3DL1 ligands. We show that expression of HLA A*2301, A*2402, or A*3201 but not HLA A*2501 protects target cells from lysis by KIR3DL1(+) NK cells. KIR3DL1(+) NK cells from donors expressing the Bw4 epitope on an HLA-A antigen only are fully functional and capable of lysing Bw4(-) target cells. HLA A25 differs at amino acid 90, close to the serologic Bw4 epitope, from A23/24/32 and from Bw4(+) HLA-B antigens. These data suggest that HLA-A antigens should be taken into consideration when assessing the potential for NK alloreactivity after hematopoietic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-137521"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-02-137521"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Stern M."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Stern M."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Velardi A."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Velardi A."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Capanni M."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Capanni M."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Mancusi A."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Mancusi A."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Ruggeri L."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/author | "Ruggeri L."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/pages | "708-710"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/pages | "708-710"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/title | "Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/title | "Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1."xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/18502829 | http://purl.uniprot.org/core/volume | "112"xsd:string |