| http://purl.uniprot.org/citations/18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18504303 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood vessel formation requires the integrated regulation of endothelial cell proliferation and branching morphogenesis, but how this coordinated regulation is achieved is not well understood. Flt-1 (vascular endothelial growth factor [VEGF] receptor 1) is a high affinity VEGF-A receptor whose loss leads to vessel overgrowth and dysmorphogenesis. We examined the ability of Flt-1 isoform transgenes to rescue the vascular development of embryonic stem cell-derived flt-1-/-mutant vessels. Endothelial proliferation was equivalently rescued by both soluble (sFlt-1) and membrane-tethered (mFlt-1) isoforms, but only sFlt-1 rescued vessel branching. Flk-1 Tyr-1173 phosphorylation was increased in flt-1-/-mutant vessels and partially rescued by the Flt-1 isoform transgenes. sFlt-1-rescued vessels exhibited more heterogeneous levels of pFlk than did mFlt-1-rescued vessels, and reporter gene expression from the flt-1 locus was also heterogeneous in developing vessels. Our data support a model whereby sFlt-1 protein is more efficient than mFlt-1 at amplifying initial expression differences, and these amplified differences set up local discontinuities in VEGF-A ligand availability that are important for proper vessel branching."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200709114"xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Zeng G."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Chappell J.C."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Patterson C."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Bautch V.L."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Kappas N.C."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Kearney J.B."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Hazarika S."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Annex B.H."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/author | "Kallianos K.G."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/pages | "847-858"xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/title | "The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching."xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18504303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18504303 |
| http://purl.uniprot.org/citations/18504303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18504303 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A4-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |
| http://purl.uniprot.org/uniprot/#_O55095-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |
| http://purl.uniprot.org/uniprot/#_P35918-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |
| http://purl.uniprot.org/uniprot/#_Q3UQZ6-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |
| http://purl.uniprot.org/uniprot/#_P35969-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |
| http://purl.uniprot.org/uniprot/#_Q3TJC1-mappedCitation-18504303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18504303 |