| http://purl.uniprot.org/citations/18505863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18505863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18505863 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding how neurons adopt particular fates is a fundamental challenge in developmental neurobiology. To address this issue, we have been studying a Caenorhabditis elegans lineage that produces the HSN motor neuron and the PHB sensory neuron, sister cells produced by the HSN/PHB precursor. We have previously shown that the novel protein HAM-1 controls the asymmetric neuroblast division in this lineage. In this study we examine tbx-2 and egl-5, genes that act in concert with ham-1 to regulate HSN and PHB fate. In screens for mutants with abnormal HSN development, we identified the T-box protein TBX-2 as being important for both HSN and PHB differentiation. TBX-2, along with HAM-1, regulates the migrations of the HSNs and prevents the PHB neurons from adopting an apoptotic fate. The homeobox gene egl-5 has been shown to regulate the migration and later differentiation of the HSN. While mutations that disrupt its function show no obvious role for EGL-5 in PHB development, loss of egl-5 in a ham-1 mutant background leads to PHB differentiation defects. Expression of EGL-5 in the HSN/PHB precursor but not in the PHB neuron suggests that EGL-5 specifies precursor fate. These observations reveal a role for both EGL-5 and TBX-2 in neural fate specification in the HSN/PHB lineage."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.108.088948"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.108.088948"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Singhvi A."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Singhvi A."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Frank C.A."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/author | "Frank C.A."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/pages | "887-898"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/pages | "887-898"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/title | "The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/title | "The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage."xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/18505863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18505863 |
| http://purl.uniprot.org/citations/18505863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18505863 |
| http://purl.uniprot.org/citations/18505863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18505863 |
| http://purl.uniprot.org/citations/18505863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18505863 |