| http://purl.uniprot.org/citations/18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508047 | http://www.w3.org/2000/01/rdf-schema#comment | "Arsenite has been well-proved to act as both an environmental carcinogen as well as a tumor therapeutic agent. AP-1 is one of the transcription factors that can be induced upon arsenite stimulation. However, the study on the mechanism and the function of the arsenite-induced AP-1 transactivation remains far complete. Here we demonstrated that high dose of arsenite induced apoptotic response in mouse fibroblasts correlating with AP-1 transactivation, which events were mediated by both IKKalpha and IKKbeta, two major protein kinases responsible for NF-kappaB activation. In addition, the regulatory effect of IKKs on the arsenite-induced AP-1 activation was delivered by sequential induction of GADD45alpha expression and the activation of MAPKK (MKK3/4/6) and MAPK (JNK and p38K)-dependent pathways. We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit. Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite-induced AP-1 transactivation through NF-kappaB activity-independent manner."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2008.04.002"xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/author | "Hu M."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/pages | "2187-2198"xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/title | "Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner."xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18508047 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18508047 |
| http://purl.uniprot.org/citations/18508047 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18508047 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T4-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_E9Q605-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_A0A494BA44-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_A0AUV3-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_E9QNL4-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_F6ULQ4-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_F6XPL0-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_O88351-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |
| http://purl.uniprot.org/uniprot/#_Q3U141-mappedCitation-18508047 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508047 |