| http://purl.uniprot.org/citations/18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508762 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have revealed that B-Raf mutations are very common in malignant melanoma and are required for tumor growth and maintenance. The majority of melanoma-associated B-Raf mutations involve a single point mutation, V600E, which results in greatly elevated B-Raf kinase activity and constitutive activation of MAPK/ERK downstream. Here we show that B-Raf(V600E) increases resistance to apoptosis induced by chemotherapeutic drugs and promotes ERK-dependent phosphorylation of the BH3-only proteins Bim and Bad that are involved in setting thresholds for apoptosis. ERK-dependent phosphorylation of Bim resulted in degradation of this BH3-only protein, whereas phosphorylation of Bad has previously been shown to result in its sequestration by 14-3-3 proteins. Consistent with this, inhibition of ERK activity in a panel of melanoma cell lines resulted in stabilization of Bim and dephosphorylation of Bad. Furthermore, apoptosis induced through overexpression of Bad or Bim was efficiently blocked by coexpression of mutant B-Raf(V600E). However, small interfering RNA-mediated silencing of Bim and Bad expression conferred only modest protection against cytotoxic drugs, whereas oncogenic B-Raf strongly protected against the same stimuli. These observations suggest that B-Raf-initiated inactivation of Bad and Bim only partly contributes to the anti-apoptotic activities of this oncogene and that other points within the cell death machinery are also targeted by deregulated ERK signaling."xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800271200"xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/author | "Brumatti G."xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/author | "Martin S.J."xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/author | "Sheridan C."xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/pages | "22128-22135"xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/title | "Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim."xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18508762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18508762 |
| http://purl.uniprot.org/citations/18508762 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18508762 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH20-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_B4DZQ9-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_B4DHN0-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_H7BZE5-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_O43521-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_Q1HBJ4-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_P28482-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_Q499G7-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_Q8WXB2-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_Q6JTU4-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/#_Q92934-mappedCitation-18508762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508762 |
| http://purl.uniprot.org/uniprot/P28482 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18508762 |