| http://purl.uniprot.org/citations/18508862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508862 | http://www.w3.org/2000/01/rdf-schema#comment | "Glia are essential components of nervous systems. However, genetic programs promoting glia development and regulating glia-neuron interactions have not been extensively explored. Here we describe transcriptional programs required for development and function of the C. elegans cephalic sheath (CEPsh) glia. We demonstrate ventral- and dorsal-restricted roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in CEPsh glia differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-related. Using mls-2 and vab-3 mutants, as well as CEPsh glia-ablated animals, we show that CEPsh glia are important for sensory dendrite extension, axon guidance/branching within the nerve ring, and nerve ring assembly. We demonstrate that UNC-6/Netrin, expressed in ventral CEPsh glia, mediates glia-dependent axon guidance. Our results suggest possible similarities between CEPsh glia development and oligodendrocyte development in vertebrates, and demonstrate that C. elegans provides a unique environment for studying glial functions in vivo."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.019547"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.019547"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Waterston R.H."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Waterston R.H."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Murray J.I."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/author | "Murray J.I."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/pages | "2263-2275"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/pages | "2263-2275"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/title | "mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/title | "mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/18508862 | http://purl.uniprot.org/core/volume | "135"xsd:string |