| http://purl.uniprot.org/citations/18508879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508879 | http://www.w3.org/2000/01/rdf-schema#comment | "Urinary tract obstruction impairs renal function and is often associated with a urinary acidification defect caused by diminished net H+ secretion and/or HCO3-reabsorption. To identify the molecular mechanisms of these defects, protein expression of key acid-base transporters were examined along the renal nephron and collecting duct of kidneys from rats subjected to 24-h bilateral ureteral obstruction (BUO), 4 days after release of BUO (BUO-R), or BUO-R rats with experimentally induced metabolic acidosis (BUO-A). Semiquantitative immunoblotting revealed that BUO caused a significant reduction in the expression of the type 3 Na+/H+ exchanger (NHE3) in the cortex (21 +/-4%), electrogenic Na+/HCO3- cotransporter (NBC1; 71 +/-5%), type 1 bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC2; 3 +/-1%), electroneutral Na+/HCO3- cotransporter (NBCn1; 46 +/-7%), and anion exchanger (pendrin; 87 +/-2%). The expression of H+-ATPase increased in the inner medullary collecting duct (152 +/-13%). These changes were confirmed by immunocytochemistry. In BUO-R rats, there was a persistent downregulation of all the acid-base transporters including H+-ATPase. Two days of NH4Cl loading reduced plasma pH and HCO3-levels in BUO-A rats. The results demonstrate that the expression of multiple renal acid-base transporters are markedly altered in response to BUO, which may be responsible for development of metabolic acidosis and contribute to the urinary acidification defect after release of the obstruction."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00425.2007"xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Kim S.W."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Wen J."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Ring T."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Nielsen S."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Frokiaer J."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/author | "Djurhuus J.C."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/pages | "F497-506"xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/title | "Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney."xsd:string |
| http://purl.uniprot.org/citations/18508879 | http://purl.uniprot.org/core/volume | "295"xsd:string |
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