| http://purl.uniprot.org/citations/18508967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18508967 | http://www.w3.org/2000/01/rdf-schema#comment | "Induced in high glucose-1 (IHG-1) is an evolutionarily conserved gene transcript upregulated by high extracellular glucose concentrations, but its function is unknown. Here, it is reported that the abundance of IHG-1 mRNA is nearly 10-fold higher in microdissected, tubule-rich renal biopsies from patients with diabetic nephropathy compared with control subjects. In the diabetic nephropathy specimens, in situ hybridization localized IHG-1 to tubular epithelial cells along with TGF-beta1 and activated Smad3, suggesting a possible role in the development of tubulointerstitial fibrosis. Supporting this possibility, IHG-1 mRNA and protein expression also increased with unilateral ureteral obstruction. In the HK-2 proximal tubule cell line, overexpression of IHG-1 increased TGF-beta1-stimulated expression of connective tissue growth factor and fibronectin. IHG-1 was found to amplify TGF-beta1-mediated transcriptional activity by increasing and prolonging phosphorylation of Smad3. Conversely, inhibition of endogenous IHG-1 with small interference RNA suppressed transcriptional responses to TGF-beta1. In summary, IHG-1, which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2007101080"xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Murphy M."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Martin F."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Howlin J."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Schmid H."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "McMahon R."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Godson C."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Kretzler M."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Brady H.R."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Furlong F."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Griffin B."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Mezzano S."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "McArdle E."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Droguett A."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/author | "Docherty N.G."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/pages | "1672-1680"xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/title | "IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18508967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18508967 |
| http://purl.uniprot.org/citations/18508967 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18508967 |
| http://purl.uniprot.org/uniprot/#_B4E366-mappedCitation-18508967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18508967 |