| http://purl.uniprot.org/citations/18509338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18509338 | http://www.w3.org/2000/01/rdf-schema#comment | "With the recent recognition of non-coding RNAs (ncRNAs) flanking many genes, a central issue is to obtain a full understanding of their potential roles in regulated gene transcription programmes, possibly through different mechanisms. Here we show that an RNA-binding protein, TLS (for translocated in liposarcoma), serves as a key transcriptional regulatory sensor of DNA damage signals that, on the basis of its allosteric modulation by RNA, specifically binds to and inhibits CREB-binding protein (CBP) and p300 histone acetyltransferase activities on a repressed gene target, cyclin D1 (CCND1) in human cell lines. Recruitment of TLS to the CCND1 promoter to cause gene-specific repression is directed by single-stranded, low-copy-number ncRNA transcripts tethered to the 5' regulatory regions of CCND1 that are induced in response to DNA damage signals. Our data suggest that signal-induced ncRNAs localized to regulatory regions of transcription units can act cooperatively as selective ligands, recruiting and modulating the activities of distinct classes of RNA-binding co-regulators in response to specific signals, providing an unexpected ncRNA/RNA-binding protein-based strategy to integrate transcriptional programmes."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature06992"xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Arai S."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Tempst P."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Pascual G."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Reichart D."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Du K."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/author | "Kurokawa R."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/pages | "126-130"xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/title | "Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription."xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://purl.uniprot.org/core/volume | "454"xsd:string |
| http://purl.uniprot.org/citations/18509338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18509338 |
| http://purl.uniprot.org/citations/18509338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18509338 |
| http://purl.uniprot.org/uniprot/P35637#attribution-89C39D24990AB5819943F1AC95D26412 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18509338 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP23-mappedCitation-18509338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18509338 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP46-mappedCitation-18509338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18509338 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPL2-mappedCitation-18509338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18509338 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPQ3-mappedCitation-18509338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18509338 |